The Metabolic Link
The Metabolic Link
Journal Club: Metabolic Overdrive in Bipolar Disorder | The Metabolic Link Ep.51
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In this journal club episode of The Metabolic Link, we explore the cutting-edge "Metabolic Overdrive Hypothesis" with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, diving into the brain’s energy dysregulation in bipolar disorder. The featured paper, "The Metabolic Overdrive Hypothesis: Hyperglycolysis and Glutaminolysis in Bipolar Mania", by authors Dr. Iain Campbell and Dr. Harry Campbell, proposes that mitochondrial dysfunction forces the brain into a hypermetabolic state, leading to manic episodes.
We discuss how this groundbreaking research links bipolar disorder to epilepsy and how therapeutic ketosis—through diet or supplementation—might restore energy balance, reduce manic episodes, and complement traditional medications.
With the potential to reshape psychiatric treatment, you won't want to miss this paper or journal club episode! Read the full paper here: https://www.nature.com/articles/s41380-024-02431-w
Special thanks to the sponsors of this episode:
- Genova Connect - Receive 15% off any of their tests with code METABOLICLINK here
- Fatty15 - Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK here
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