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The Metabolic Link

Understanding The Lean Mass Hyper Responder w/ Dr. Nick Norwitz and Dave Feldman | The Metabolic Link Ep. 32

January 12, 2024 Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field Episode 32
The Metabolic Link
Understanding The Lean Mass Hyper Responder w/ Dr. Nick Norwitz and Dave Feldman | The Metabolic Link Ep. 32
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The Metabolic Link
Understanding The Lean Mass Hyper Responder w/ Dr. Nick Norwitz and Dave Feldman | The Metabolic Link Ep. 32
Jan 12, 2024 Episode 32
Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field

We’ve just launched an extra and exciting episode of The Metabolic Link podcast! It features an eye-opening conversation between our host Dominic D’Agostino PhD, and guests Dave Feldman and Dr. Nick Norwitz, two researchers and MHS 2024 speakers spearheading investigations into the lean mass hyperresponder (LMHR) phenotype.

Dave Feldman is a software engineer who became deeply interested in lipidology after seeing his cholesterol spike on a low-carb, high-fat diet. He has since performed self-experiments and published several papers on the possible mechanisms behind LMHR. He is currently conducting a clinical study out of UCLA through his newly formed public charity, the Citizen Science Foundation.

Nicholas Norwitz completed his PhD at the University of Oxford and his thesis focused on ketone metabolism and neurodegenerative diseases. He is currently a medical student at Harvard Medical School.

In this episode Dave, Dr. Norwitz, and Dr. D'Agostino dive into…

  • The debate around whether saturated fat drives increased LDL levels, especially in the LMHR phenotype.
  • The "Lipid Energy Model" hypothesizing a metabolic/physiological process underlying LMHR phenotype.
  •  Concerns about erroneously grouping lean mass hyperresponders with familial hypercholesterolemia patients.
  •  The importance of separating discussions of underlying mechanism from clinical recommendations.
  • Their vision for the future direction of LMHR research and public education on this topic.

Be sure to secure your spot at MHS 2024 in Clearwater Beach, Florida, where Dave and Nick will be presenting their latest research! Both virtual and in-person seats are still available at metabolichealthsummit.com.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.

Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

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Show Notes

We’ve just launched an extra and exciting episode of The Metabolic Link podcast! It features an eye-opening conversation between our host Dominic D’Agostino PhD, and guests Dave Feldman and Dr. Nick Norwitz, two researchers and MHS 2024 speakers spearheading investigations into the lean mass hyperresponder (LMHR) phenotype.

Dave Feldman is a software engineer who became deeply interested in lipidology after seeing his cholesterol spike on a low-carb, high-fat diet. He has since performed self-experiments and published several papers on the possible mechanisms behind LMHR. He is currently conducting a clinical study out of UCLA through his newly formed public charity, the Citizen Science Foundation.

Nicholas Norwitz completed his PhD at the University of Oxford and his thesis focused on ketone metabolism and neurodegenerative diseases. He is currently a medical student at Harvard Medical School.

In this episode Dave, Dr. Norwitz, and Dr. D'Agostino dive into…

  • The debate around whether saturated fat drives increased LDL levels, especially in the LMHR phenotype.
  • The "Lipid Energy Model" hypothesizing a metabolic/physiological process underlying LMHR phenotype.
  •  Concerns about erroneously grouping lean mass hyperresponders with familial hypercholesterolemia patients.
  •  The importance of separating discussions of underlying mechanism from clinical recommendations.
  • Their vision for the future direction of LMHR research and public education on this topic.

Be sure to secure your spot at MHS 2024 in Clearwater Beach, Florida, where Dave and Nick will be presenting their latest research! Both virtual and in-person seats are still available at metabolichealthsummit.com.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.

Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.